Article
Toward precision prescribing for methadone: Determinants of methadone deposition.
PloS one - 1 Jan 2020
Talal Andrew H, Ding Yuxin, Venuto Charles S, Chakan Lindsay M, McLeod Anthony, Dharia Arpan, Morse Gene D, Brown Lawrence S, Markatou Marianthi, Kharasch Evan D
Abstract excerpt
BACKGROUND: Despite the World Health Organization listing methadone as an essential medication, effective dose selection is challenging, especially in racial and ethnic minority populations. Subtherapeutic doses can result in withdrawal symptoms while supratherapeutic doses can result in overdose and death. Although CYP3A4 was conventionally considered the principal methadone metabolizing enzyme, more recent data...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.