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A minor population of macrophage-tropic HIV-1 variants is identified in recrudescing viremia following analytic treatment interruption

16 Apr 2020

Abstract excerpt

HIV-1 persists in cellular reservoirs that can reignite viremia if antiretroviral therapy (ART) is interrupted. Therefore, insight into the nature of those reservoirs may be revealed from the composition of recrudescing viremia following treatment cessation. A minor population of macrophage-tropic (M-tropic) viruses was identified in a library of recombinant viruses constructed with individual envelope genes that...

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PMID: 32300019
DOI: 10.1073/pnas.1917034117

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