Article
Gene-to-gene interactions and the association of TP53, XRCC1, TNFα, HMMR, MDM2 and PALB2 with breast cancer in Kyrgyz females.
Breast cancer (Tokyo, Japan) - 1 Sept 2020
Isakova J T, Vinnikov D, Kipen V N, Talaibekova E T, Aldashev A A, Aldasheva N M, Makieva K B, Semetei Kyzy A, Bukuev N M, Tilekov E A, Shaimbetov B O, Kudaibergenova I O
Abstract excerpt
BACKGROUND: At present, little is known about the genetic background of breast cancer (BC) in Kyrgyz. Therefore, the aim of this study was to assess gene-to-gene interactions and the contribution of p.Arg72Pro (TP53 gene), p.Gln399Arg (XRCC1 gene), p.Arg194Trp (XRCC1 gene), g.4682G > A (TNFα gene), p.Val353Ala (HMMR gene), c.14 + 309 T > G (MDM2 gene) and g.38444 T > G (PALB2 gene) polymorphic loci in breast...
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