Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein Levels

11 Apr 2020

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disease in which activated lymphocytes affect the central nervous system. Increase of reactive oxygen species (ROS), impairment of mitochondria-mediated apoptosis and mitochondrial alterations have been reported in peripheral lymphocytes of MS patients. Mitochondria-mediated apoptosis is regulated by several mechanisms and proteins. Among others, optic atrophy 1 (OPA1)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hereditary Neurological Disorders
Share to Mitochondrial Function and Pathology
Share to Multiple Sclerosis Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32290388
DOI: 10.3390/biomedicines8040085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PBMC of Multiple Sclerosis Patients Show Deregulation of OPA1 Processing Associated with Increased ROS and PHB2 Protein LevelsPMID 32290388Read ↗

The Pathophysiological Role of Mitochondrial Oxidative Stress in Rheumatic DiseasesSemantic proximity Read ↗

Targeted RNAseq Revealed the Gene Expression Signature of Ferroptosis-Related Processes Associated with Disease Severity in Patients with Multiple SclerosisSemantic proximity Read ↗

Oxidative stress and its impact on neurons and glia in multiple sclerosis lesionsSemantic proximity Read ↗

Genetic Alterations in Patients with Two Clinical Phenotypes of Multiple Sclerosis.Semantic proximity Read ↗

Analysis of opa1 isoforms expression and apoptosis regulation in autosomal dominant optic atrophy (ADOA) patients with mutations in the opa1 gene.Semantic proximity Read ↗

The Role of Hemoglobin Subunit Delta in the Immunopathy of Multiple Sclerosis: Mitochondria MattersSemantic proximity Read ↗

Epigenetic and Mitochondrial Metabolic Dysfunction in Multiple Sclerosis: A Review of Herbal Drug Approaches and Current Clinical TrialsSemantic proximity Read ↗

Impaired Myelination in Multiple Sclerosis Organoids: p21 Links Oligodendrocyte Dysfunction to Disease SubtypeSemantic proximity Read ↗

Peripheral redox biomarkers in multiple sclerosis: associations with phenotype, cognition, and fatigue.Semantic proximity Read ↗

Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosisSemantic proximity Read ↗

Therapeutic Effect of the Mitochondria-Targeted Antioxidant SkQ1 on the Culture Model of Multiple SclerosisSemantic proximity Read ↗

OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.