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Article

OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy.

Neurology - 2 Oct 2012

Sitarz Kamil S, Almind Gitte J, Horvath Rita, Czermin Birgit, Grønskov Karen, Pyle Angela, Taylor Robert W, Larsen Michael, Chinnery Patrick F, Yu-Wai-Man Patrick

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Identifiers

PMID: 22993284
DOI: 10.1212/WNL.0b013e31826d5f60
PMCID: PMC3525295

Genes

OPA1

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Related research

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OPA1 mutations induce mtDNA proliferation in leukocytes of patients with dominant optic atrophy.PMID 22993284Read ↗

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OPA1 mutation affects autophagy and triggers senescence in autosomal dominant optic atrophy plus fibroblasts.Semantic proximity Read ↗

OPA1: How much do we know to approach therapy?Semantic proximity Read ↗

mtDNA mutations that cause optic neuropathy: how do we know?Semantic proximity Read ↗

OPA1 mutations cause cytochrome c oxidase deficiency due to loss of wild-type mtDNA molecules.Semantic proximity Read ↗

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCsSemantic proximity Read ↗

Mitochondrial DNA content is decreased in autosomal dominant optic atrophy.Semantic proximity Read ↗

OPA1 (Kjer type) dominant optic atrophy: a novel mitochondrial disease.Semantic proximity Read ↗

The human OPA1delTTAG mutation induces premature age-related systemic neurodegeneration in mouse.Semantic proximity Read ↗

OPA1 Dominant Optic Atrophy: Pathogenesis and Therapeutic Targets.Semantic proximity Read ↗

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