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Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts

27 Oct 2015

Abstract excerpt

The ability to generate integration-free induced hepatocyte-like cells (iHeps) from somatic fibroblasts has the potential to advance their clinical application. Here, we have generated integration-free, functional, and expandable iHeps from mouse somatic fibroblasts. To elicit this direct conversion, we took advantage of an oriP/EBNA1-based episomal system to deliver a set of transcription factors, Gata4, Hnf1a,...

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PMID: 26503743
DOI: 10.1038/srep15706

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