Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.

doi:10.1016/j.bbi.2020.04.007

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Article

Two single nucleotide polymorphisms in IL13 and IL13RA1 from individuals with idiopathic Parkinson's disease increase cellular susceptibility to oxidative stress.

Brain, behavior, and immunity - 1 Aug 2020

Aguirre Carlos A, Concetta Morale Maria, Peng Qian, Sanchez-Alavez Manuel, Cintrón-Colón Rigo, Feng Kaige, Fazelpour Sherwin, Maher Pamela, Conti Bruno

Abstract excerpt

The human genes for interleukin 13 (IL-13) and its receptor alpha 1 (IL-13Rα1) are in chromosomal regions associated with Parkinson's disease (PD). The interaction of IL-13 with its receptor increases the susceptibility of mouse dopaminergic neurons to oxidative stress. We identified two rare single SNPs in IL13 and IL13RA1 and measured their cytotoxic effects. rs148077750 is a missense leucine to proline...

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Identifiers

PMID: 32276028
DOI: 10.1016/j.bbi.2020.04.007
PMCID: PMC9012133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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