Article
Cutting edge: IL-13Rα1 expression in dopaminergic neurons contributes to their oxidative stress-mediated loss following chronic peripheral treatment with lipopolysaccharide.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2012
Morrison Brad E, Marcondes Maria Cecilia Garibaldi, Nomura Daniel K, Sanchez-Alavez Manuel, Sanchez-Gonzalez Alejandro, Saar Indrek, Kim Kwang-Soo, Bartfai Tamas, Maher Pamela, Sugama Shuei, Conti Bruno
Abstract excerpt
Inflammation and its mediators, including cytokines and reactive oxygen species, are thought to contribute to neurodegeneration. In the mouse brain, we found that IL-13Rα1 was expressed in the dopaminergic (DA) neurons of the substantia nigra pars compacta, which are preferentially lost in human...
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