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A single nucleotide polymorphism of porcine MX2 gene provides antiviral activity against vesicular stomatitis virus.

Immunogenetics - 1 Jan 2014

Sasaki Keisuke, Tungtrakoolsub Pullop, Morozumi Takeya, Uenishi Hirohide, Kawahara Manabu, Watanabe Tomomasa

Abstract excerpt

The objective was to determine if single nucleotide polymorphisms (SNPs) in porcine MX2 gene affect its antiviral potential. MX proteins are known to suppress the multiplication of several viruses, including influenza virus and vesicular stomatitis virus (VSV). In domestic animals possessing highly polymorphic genome, our previous research indicated that a specific SNP in chicken Mx gene was responsible for its...

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PMID: 24232602
DOI: 10.1007/s00251-013-0745-2

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