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Article

GTPase activity of porcine Mx1 plays a dominant role in inhibiting the N-Nsp9 interaction and thus inhibiting PRRSV replication.

Journal of virology - 16 Apr 2024

Hu Yue, Wu Xiangju, Tian Yunfei, Jiang Dandan, Ren Jinrui, Li Ziyong, Ding Xiuliang, Zhang Quanfang, Yoo Dongwan, Miller Laura C, Lee Changhee, Cong Xiaoyan, Li Juntong, Du Yijun, Qi Jing

Abstract excerpt

Porcine Mx1 is a type of interferon-induced GTPase that inhibits the replication of certain RNA viruses. However, the antiviral effects and the underlying mechanism of porcine Mx1 for porcine reproductive and respiratory syndrome virus (PRRSV) remain unknown. In this study, we demonstrated that porcine Mx1 could significantly inhibit PRRSV replication in MARC-145 cells. By Mx1 segment analysis, it was indicated...

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Identifiers

PMID: 38436247
DOI: 10.1128/jvi.01844-23
PMCID: PMC11019876

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