Inhibition of a Large Double-Stranded DNA Virus by MxA Protein

doi:10.1128/jvi.00781-08

Article

Inhibition of a Large Double-Stranded DNA Virus by MxA Protein

25 Dec 2008

Abstract excerpt

Increasing evidence points to the importance of the interferon (IFN) response in determining the host range and virulence of African swine fever virus (ASFV). Infection with attenuated strains of ASFV leads to the upregulation of genes controlled by IFN pathways, including myxovirus resistance (Mx) genes that are potent effectors of the antiviral state. Mx gene products are known to inhibit the replication of...

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