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Article

A Protocol for the Study of Polymorphisms and Response to Metformin in Patients with Type 2 Diabetes in Trinidad.

Ethnicity & disease - 1 Jan 2020

Clement Yuri, Singh Shamjeet, Motilal Shastri, Maharaj Rohan, Nunez-Smith Marcella

Abstract excerpt

Background: Metformin is the drug of first choice in people newly diagnosed with type 2 diabetes. Most patients respond to metformin monotherapy, but many others remain uncontrolled even at maximal doses. Although non-adherence is a major contributor to non-response, genetic polymorphisms of organic cation transporters play an important role in clinical response. We hypothesize that genetic variants are partly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32269463
DOI: 10.18865/ed.30.S1.211
PMCID: PMC7138437

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