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Article

Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages.

Journal for immunotherapy of cancer - 1 Apr 2020

Di Martile Marta, Farini Valentina, Consonni Francesca Maria, Trisciuoglio Daniela, Desideri Marianna, Valentini Elisabetta, D'Aguanno Simona, Tupone Maria Grazia, Buglioni Simonetta, Ercolani Cristiana, Gallo Enzo, Amadio Bruno, Terrenato Irene, Foddai Maria Laura, Sica Antonio, Del Bufalo Donatella

Abstract excerpt

BACKGROUND: A bidirectional crosstalk between tumor cells and the surrounding microenvironment contributes to tumor progression and response to therapy. Our previous studies have demonstrated that bcl-2 affects melanoma progression and regulates the tumor microenvironment. The aim of this study was to evaluate whether bcl-2 expression in melanoma cells could influence tumor-promoting functions of tumor-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32269145
DOI: 10.1136/jitc-2019-000489
PMCID: PMC7254128

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