Bcl‐2 overexpression in melanoma cells increases tumor progression‐associated properties and in vivo tumor growth

Abstract excerpt

In this study, we demonstrated that bcl-2 overexpression in human melanoma cells consistently enhanced the activity of multiple metastasis-related proteinases, in vitro cell invasion, and in vivo tumor growth. In particular, by using the M14 parental cell line, the MN8 control clone, and two bcl-2 overexpressing derivatives, we found that bcl-2 overexpressing cells exposed to hypoxia, when compared to parental...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cell Adhesion Molecules Research
• Share to Protease and Inhibitor Mechanisms
• Share to Proteoglycans and glycosaminoglycans research