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Article

PLK1 is required for chromosome compaction and microtubule organization in mouse oocytes

28 May 2020

Abstract excerpt

cKO oocytes either failed to organize α-tubulin or developed an abnormally small bipolar spindle. These abnormalities were attributed to aberrant release of the microtubule organizing center (MTOC) linker protein, C-NAP1, and the failure to recruit MTOC components and liquid-like spindle domain (LISD) factors. Ultimately, these defects result in meiosis I arrest before homologous chromosome segregation.

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PMID: 32267211
DOI: 10.1091/mbc.e19-12-0701

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