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Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis

8 Apr 2024

Abstract excerpt

Kinesin family member 3A (KIF3A) is a microtubule-oriented motor protein that belongs to the kinesin-2 family for regulating intracellular transport and microtubule movement. In this study, we characterized the critical roles of KIF3A during mouse oocyte meiosis. We found that KIF3A associated with microtubules during meiosis and depletion of KIF3A resulted in oocyte maturation defects. LC-MS data indicated that...

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PMID: 38587639
DOI: 10.1007/s00018-024-05213-3

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