Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.

The Journal of cell biology - 1 Jun 2020

Odierna G Lorenzo, Kerwin Sarah K, Harris Lucy E, Shin Grace Ji-Eun, Lavidis Nickolas A, Noakes Peter G, Millard S Sean

Abstract excerpt

Dscam2 is a cell surface protein required for neuronal development in Drosophila; it can promote neural wiring through homophilic recognition that leads to either adhesion or repulsion between neurites. Here, we report that Dscam2 also plays a post-developmental role in suppressing synaptic strength. This function is dependent on one of two distinct extracellular isoforms of the protein and is autonomous to motor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neural Cell Adhesion Molecules

Share to Neurogenesis

Share to Neuromuscular Junction

Share to Peripheral Nervous System

Share to Phosphatidylinositols

Share to Phosphoinositide-3 Kinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 32259198
DOI: 10.1083/jcb.201909143
PMCID: PMC7265308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dscam2 suppresses synaptic strength through a PI3K-dependent endosomal pathway.PMID 32259198Read ↗

DSCAM gene triplication causes excessive GABAergic synapses in the neocortex in Down syndrome mouse modelsSemantic proximity Read ↗

PTPN11/Corkscrew Activates Local Presynaptic Mapk Signaling to Regulate Synapsin, Synaptic Vesicle Pools, and Neurotransmission Strength, with a Dual Requirement in Neurons and Glia.Semantic proximity Read ↗

ASTN2 modulates synaptic strength by trafficking and degradation of surface proteinsSemantic proximity Read ↗

Restoring DSCAM expression rescues neuronal morphology and axon guidance deficits in Down syndromeSemantic proximity Read ↗

<i>Dscam</i> gene triplication causes neocortical overinhibition in Down syndromeSemantic proximity Read ↗

Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins.Semantic proximity Read ↗

Genetic dissection of the Drosophila BLOC-1 complex reveals distinctions in synaptic localization and homeostatic plasticity.Semantic proximity Read ↗

Sorting Out Sorting Nexins Functions in the Nervous System in Health and DiseaseSemantic proximity Read ↗

Modeling AP2M1 Developmental and Epileptic Encephalopathy in DrosophilaSemantic proximity Read ↗

Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog.Semantic proximity Read ↗

Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons.Semantic proximity Read ↗

A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter releaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.