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Article

Brief Report: APOL1 Renal Risk Variants Are Associated With Chronic Kidney Disease in Children and Youth With Perinatal HIV Infection.

Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2016

Purswani Murli U, Patel Kunjal, Winkler Cheryl A, Spector Stephen A, Hazra Rohan, Seage George R, Mofenson Lynne, Karalius Brad, Scott Gwendolyn B, Van Dyke Russell B, Kopp Jeffrey B

Abstract excerpt

APOL1 renal risk alleles are associated with chronic kidney disease (CKD) in adults, with the strongest effect being for HIV-associated nephropathy. Their role in youth with perinatal HIV-1 infection (PHIV) has not been studied. In a nested case-control study of 451 PHIV participants in the Pediatric HIV/AIDS Cohort Study, we found a 3.5-fold increased odds of CKD in those carrying high-risk APOL1 genotypes using...

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Identifiers

PMID: 27035887
DOI: 10.1097/QAI.0000000000001010
PMCID: PMC4981510

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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