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Article

GRM7 gene mutations and consequences for neurodevelopment.

Pharmacology, biochemistry, and behavior - 1 Apr 2023

Freitas Geanne A, Niswender Colleen M

Abstract excerpt

The metabotropic glutamate receptor 7 (mGlu7), encoded by the GRM7 gene in humans, is a presynaptic, G protein-coupled glutamate receptor that is essential for modulating neurotransmission. Mutations in or reduced expression of GRM7 have been identified in different genetic neurodevelopmental disorders (NDDs), and rare biallelic missense variants have been proposed to underlie a subset of NDDs. Clinical GRM7...

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Identifiers

PMID: 37003303
DOI: 10.1016/j.pbb.2023.173546
PMCID: PMC10192299

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