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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.

Cancer cell - 11 May 2020

Guerra Stephanie L, Maertens Ophélia, Kuzmickas Ryan, De Raedt Thomas, Adeyemi Richard O, Guild Caroline J, Guillemette Shawna, Redig Amanda J, Chambers Emily S, Xu Man, Tiv Hong, Santagata Sandro, Jänne Pasi A, Elledge Stephen J, Cichowski Karen

Abstract excerpt

While KRAS mutations are common in non-small cell lung cancer (NSCLC), effective treatments are lacking. Here, we report that half of KRAS-mutant NSCLCs aberrantly express the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, which confers sensitivity to combined BET/MEK inhibitors in xenograft and PDX models. Efficacy of the combination is dependent on suppression of HOXC10 by BET...

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PMID: 32243838
DOI: 10.1016/j.ccell.2020.03.004
PMCID: PMC10805385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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