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Article

EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation.

Cancer research - 15 May 2014

Wang Meng, Kern Ashley M, Hülskötter Marieke, Greninger Patricia, Singh Anurag, Pan Yunfeng, Chowdhury Dipanjan, Krause Mechthild, Baumann Michael, Benes Cyril H, Efstathiou Jason A, Settleman Jeff, Willers Henning

Abstract excerpt

Therapeutics that target the epidermal growth factor receptor (EGFR) can enhance the cytotoxic effects of ionizing radiation (IR). However, predictive genomic biomarkers of this radiosensitization have remained elusive. By screening 40 non-small cell lung cancer cell (NSCLC) lines, we established a surprising positive correlation between the presence of a KRAS mutation and radiosensitization by the EGFR...

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Identifiers

PMID: 24648348
DOI: 10.1158/0008-5472.CAN-13-3157
PMCID: PMC4278592

Genes

EGFR
KRAS

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