Article
Genotype-environment interactions in microsatellite stable/microsatellite instability-low colorectal cancer: results from a genome-wide association study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2011
Figueiredo Jane C, Lewinger Juan Pablo, Song Chi, Campbell Peter T, Conti David V, Edlund Christopher K, Duggan Dave J, Rangrej Jagadish, Lemire Mathieu, Hudson Thomas, Zanke Brent, Cotterchio Michelle, Gallinger Steven, Jenkins Mark, Hopper John, Haile Robert, Newcomb Polly, Potter John, Baron John A, Le Marchand Loic, Casey Graham
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have led to the identification of a number of common susceptibility loci for colorectal cancer (CRC); however, none of these GWAS have considered gene-environment (G × E) interactions. Therefore, it is unclear whether current hits are modified by environmental exposures or whether there are additional hits whose effects are dependent on environmental exposures....
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