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Article

Expression of ALS-linked SOD1 Mutation in Motoneurons or Myotubes Induces Differential Effects on Neuromuscular Function In vitro.

Neuroscience - 21 May 2020

Benlefki Salim, Sanchez-Vicente Ana, Milla Vanessa, Lucas Olivier, Soulard Claire, Younes Richard, Gergely Csilla, Bowerman Mélissa, Raoul Cédric, Scamps Frédérique, Hilaire Cécile

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that selectively affects upper and lower motoneurons. Dismantlement of the neuromuscular junction (NMJ) is an early pathological hallmark of the disease whose cellular origin remains still debated. We developed an in vitro NMJ model to investigate the differential contribution of motoneurons and muscle cells expressing ALS-causing mutation...

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Identifiers

PMID: 32234507
DOI: 10.1016/j.neuroscience.2020.03.044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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