A Microfluidic Chip for Screening and Sequencing of Monoclonal Antibody at a Single-Cell Level

Abstract excerpt

The pairing of heavy and light chains of an antibody decides the specificity of monoclonal antibodies (mAbs). Acquisition of the genes encoding variable regions of paired heavy and light chains (V H:V L ) is crucial, but it is a labor- and cost-intensive process in traditional methods. The emerging microfluidic chips have brought us to a portal of directly acquiring natively paired V H:V L genes by sequencing...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Microfluidic and Bio-sensing Technologies
• Share to Monoclonal and Polyclonal Antibodies Research