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Lymphopenia in primary Sjögren’s syndrome is associated with premature aging of naïve CD4+ T cells

1 Mar 2020

Abstract excerpt

OBJECTIVE: To investigate peripheral lymphopenia, a frequent finding in primary Sjögren's syndrome (pSS) associated with higher disease activity and increased mortality. METHODS: Prospective, cross-sectional study of consecutive patients with pSS (n = 66) and healthy controls (n = 181). Lymphocyte subsets were analysed by flow cytometry, naïve (CD45RA+) and memory (CD45RO+) CD4+ T cells were purified by MACS...

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PMID: 32227243
DOI: 10.1093/rheumatology/keaa105

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