Article
Infectious Complications Predict Premature CD8+ T-cell Senescence in CD40 Ligand-Deficient Patients.
Journal of clinical immunology - 1 May 2021
Shin Junghee J, Catanzaro Jason, Yonkof Jennifer R, Delmonte Ottavia, Sacco Keith, Shin Min Sun, Reddy Srikar, Whittington Paula J, Soffer Gary, Mustillo Peter J, Sullivan Kathleen E, Notarangelo Luigi D, Abraham Roshini S, Romberg Neil, Kang Insoo
Abstract excerpt
PURPOSE: CD40 ligand (CD40L)-deficient patients display increased susceptibilities to infections that can be mitigated with effective prophylactic strategies including immunoglobulin G (IgG) replacement and prophylactic antibiotics. CD8+ T-cell senescence has been described in CD40L deficiency, but it is unclear if this is an intrinsic feature of the disease or secondary to infectious exposures. To address this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.