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Article

ADAMs family and relatives in cardiovascular physiology and pathology.

Journal of molecular and cellular cardiology - 1 Apr 2016

Zhang Pu, Shen Mengcheng, Fernandez-Patron Carlos, Kassiri Zamaneh

Abstract excerpt

A disintegrin and metalloproteinases (ADAMs) are a family of membrane-bound proteases. ADAM-TSs (ADAMs with thrombospondin domains) are a close relative of ADAMs that are present in soluble form in the extracellular space. Dysregulated production or function of these enzymes has been associated with pathologies such as cancer, asthma, Alzheimer's and cardiovascular diseases. ADAMs contribute to angiogenesis,...

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PMID: 26522853
DOI: 10.1016/j.yjmcc.2015.10.031

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