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ADAMTS proteases in cardiovascular physiology and disease

1 Dec 2020

Abstract excerpt

The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family comprises 19 proteases that regulate the structure and function of extracellular proteins in the extracellular matrix and blood. The best characterized cardiovascular role is that of ADAMTS-13 in blood. Moderately low ADAMTS-13 levels increase the risk of ischeamic stroke and very low levels (less than 10%) can cause thrombotic...

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PMID: 33352066
DOI: 10.1098/rsob.200333

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