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Article

Integrated analysis of canine soft tissue sarcomas identifies recurrent mutations in TP53, KMT genes and PDGFB fusions.

Scientific reports - 27 Jun 2023

Das Sunetra, Idate Rupa, Lana Susan E, Regan Daniel P, Duval Dawn L

Abstract excerpt

Soft tissue sarcomas (STS) are a heterogenous group of mesenchymal tumors representing over 50 distinct types with overlapping histological features and non-specific anatomical locations. Currently, localized sarcomas are treated with surgery + / - radiation in both humans and dogs with few molecularly targeted therapeutic options. However, to improve precision-based cancer therapy through trials in pet dogs...

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Identifiers

PMID: 37369741
DOI: 10.1038/s41598-023-37266-y
PMCID: PMC10300023

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