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Canine Histiocytic and Hemophagocytic Histiocytic Sarcomas Display KRAS and Extensive PTPN11/SHP2 Mutations and Respond In Vitro to MEK Inhibition by Cobimetinib.

Genes - 9 Aug 2024

Yang Ya-Ting, Engleberg Alexander I, Kapoor Ishana, Kitagawa Keita, Hilburger Sara A, Thaiwong-Nebelung Tuddow, Yuzbasiyan-Gurkan Vilma

Abstract excerpt

Histiocytic sarcoma (HS) is a rare and highly aggressive cancer in humans and dogs. In dogs, it has a high prevalence in certain breeds, such as Bernese mountain dogs (BMDs) and flat-coated retrievers. Hemophagocytic histiocytic sarcoma (HHS) is a unique form of HS that presents with erythrophagocytosis. Due to its rareness, the study of HHS is very limited, and mutations in canine HHS patients have not been...

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PMID: 39202410
DOI: 10.3390/genes15081050
PMCID: PMC11353564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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