Article

SMALL ALPHAHERPESVIRUS LATENCY-ASSOCIATED PROMOTERS DRIVE EFFICIENT AND LONG-TERM TRANSGENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEM

2019-12-31

Abstract excerpt

Recombinant adeno-associated viral vectors (rAAV) are used as gene therapy vectors to treat central nervous system (CNS) diseases. Despite their safety and broad tropism, important issues need to be corrected such as the limited payload capacity and the lack of small gene promoters providing long-term, pan-neuronal transgene expression in the CNS. Commonly used gene promoters are relatively large and can be repres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d89c38b0-80b0-58c0-a8fc-38a012f2e469
DOI: 10.1101/2019.12.31.891903

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMALL ALPHAHERPESVIRUS LATENCY-ASSOCIATED PROMOTERS DRIVE EFFICIENT AND LONG-TERM TRANSGENE EXPRESSION IN THE CENTRAL NERVOUS SYSTEMDOI 10.1101/2019.12.31.891903Read

Small Alphaherpesvirus Latency-Associated Promoters Drive Efficient and Long-Term Transgene Expression in the CNSSemantic proximity Read

The Alphaherpesvirus Latency Associated Promoter 2 (LAP2) Drives Strong Transgene Expression in Peripheral Tissue Depending on Administration Route and AAV SerotypeSemantic proximity Read

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous SystemSemantic proximity Read

Simple and Highly Specific Targeting of Resident Microglia with Adeno-Associated VirusSemantic proximity Read

Alphaviruses: Semliki Forest Virus and Sindbis Virus Vectors for Gene Transfer into NeuronsSemantic proximity Read

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates, and humansSemantic proximity Read

Spatiotemporal dynamics of alphaherpesviral latency and reactivation in the murine central nervous systemSemantic proximity Read

Adeno-Associated Virus (AAV) Vectors in the CNSSemantic proximity Read

Designing and optimizing AAV-mediated gene therapy for neurodegenerative diseases: from bench to bedsideSemantic proximity Read

Viral strategies for studying the brain, including a replication‐restricted self‐amplifying delta‐G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi‐like expressionSemantic proximity Read

Biology of adeno-associated viral vectors in the central nervous systemSemantic proximity Read

Capsid-Engineering for Central Nervous System-Directed Gene Therapy with Adeno-Associated Virus VectorsSemantic proximity Read