Article
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 18 Jul 2026
Alsabbagh Mohamed, Hubrack Satanay Z, Gamgoum Lara, Osman Maryiam J A, Ford Katherine E, Al Shakaki Alya, Robay Amal, Sarakbi Housam, Al Emadi Samar, Mackeh Rafah, Fakhro Khalid A, Lo Bernice
Abstract excerpt
BACKGROUND: A20 is an anti-inflammatory protein that suppresses nuclear factor-κB (NF-κB)-mediated inflammatory gene expression and inhibits cell death. Disruption of A20 function results in defective suppression of the NF-κB pathway, manifesting in diverse autoimmune and autoinflammatory conditions. While autosomal dominant A20 mutations have been identified to cause autoinflammatory disease, recessive A20...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.