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Article

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.

The EMBO journal - 3 Oct 2012

Tokunaga Fuminori, Nishimasu Hiroshi, Ishitani Ryuichiro, Goto Eiji, Noguchi Takuya, Mio Kazuhiro, Kamei Kiyoko, Ma Averil, Iwai Kazuhiro, Nureki Osamu

Abstract excerpt

LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF-κB pathway through linear polyubiquitination of NEMO (NF-κB essential modulator, also known as IKKγ) and RIP1. However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppresses LUBAC-mediated NF-κB activation by binding linear polyubiquitin via the C-terminal seventh zinc finger (ZF7),...

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Share to Deubiquitinating Enzyme CYLD
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Tumor Necrosis Factor

Share to Tumor Necrosis Factor alpha-Induced Protein 3

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Source

Open in PubMed Open full text

Identifiers

PMID: 23032187
DOI: 10.1038/emboj.2012.241
PMCID: PMC3463848

Genes

CYLD
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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