Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2010

Pinto Alvaro P, Miron Alexander, Yassin Yosuf, Monte Nicolas, Woo Terri Y C, Mehra Karishma K, Medeiros Fabiola, Crum Christopher P

Abstract excerpt

Differentiated vulvar intraepithelial neoplasia is a unique precursor to vulvar squamous cell carcinoma that is typically HPV-negative and frequently associated with nuclear p53 staining. These features imply a mode of pathogenesis involving somatic mutations. However, the genetic relationship of differentiated vulvar intraepithelial neoplasm and vulvar squamous cell carcinoma and the role of Tp53 mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma in Situ
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Immunoenzyme Techniques

Share to Microdissection

Share to Neoplasms, Multiple Primary

Share to Tumor Suppressor Protein p53

Share to Vulvar Neoplasms

Source

Identifiers

PMID: 20062014
DOI: 10.1038/modpathol.2009.179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differentiated vulvar intraepithelial neoplasia contains Tp53 mutations and is genetically linked to vulvar squamous cell carcinoma.PMID 20062014Read ↗

Squamous Precursor Lesions of the Vulva: A Practical Approach.Semantic proximity Read ↗

Differentiated exophytic vulvar intraepithelial lesions are genetically distinct from keratinizing squamous cell carcinomas and contain mutations in PIK3CA.Semantic proximity Read ↗

Major p53 immunohistochemical patterns in in situ and invasive squamous cell carcinomas of the vulva and correlation with TP53 mutation status.Semantic proximity Read ↗

Molecular events in the pathogenesis of vulvar squamous cell carcinoma.Semantic proximity Read ↗

The etiologic role of HPV in vulvar squamous cell carcinoma fine tuned.Semantic proximity Read ↗

Role of TP53 mutations in vulvar carcinomas.Semantic proximity Read ↗

Molecular and microenvironmental landscapes of human papillomavirus-independent invasive squamous cell carcinoma of the vulva.Semantic proximity Read ↗

TP53 mutations in vulval lichen sclerosus adjacent to squamous cell carcinoma of the vulva.Semantic proximity Read ↗

Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy.Semantic proximity Read ↗

Molecular Subtypes of Vulvar Squamous Cell Carcinoma: the significance of HPV-independent/p53 Wild TypeSemantic proximity Read ↗

Genetic changes during the multistage pathogenesis of human papillomavirus positive and negative vulvar carcinomas.Semantic proximity Read ↗

Verruciform Acanthotic Vulvar Intraepithelial Neoplasia Harbors Recurrent Genomic Alterations Found in HPV-independent Squamous Cell CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.