Article
An update on molecular research of pancreatic adenocarcinoma.
Anti-cancer agents in medicinal chemistry - 1 Jun 2011
Krautz Christian, Rückert Felix, Saeger Hans-Detlev, Pilarsky Christian, Grützmann Robert
Abstract excerpt
INTRODUCTION: This review provides an overview of the molecular mechanisms and pathways known to enhance development and progression of pancreatic ductal adenocarcinoma (PDAC). RESULTS: Today, the concept that progression of epithelial precursor lesions leads to invasive PDAC as a result of accumulating mutation in K-ras, p16(INK4A), p53 and Smad4 is widely accepted. Multiple signaling pathways that PDAC utilizes...
Topics
- Carcinoma, Pancreatic Ductal
- Humans
- Mutation
- Signal Transduction
- Tumor Microenvironment