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NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer

14 Feb 2020

Abstract excerpt

Oncolytic viruses (OVs) can trigger profound innate and adaptive immune responses, which have the potential both to potentiate and reduce the activity of OVs. Natural killer (NK) cells can mediate potent anti-viral and anti-tumoral responses, but there are no data on the role of NK cells in oncolytic adenovirus activity. Here, we have used two different oncolytic adenoviruses—the Ad5 E1A CR2-deletion mutant dl...

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PMID: 32195317
DOI: 10.1016/j.omto.2020.02.001

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