Article
Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.
PloS one - 1 Jan 2011
Jensen Helle, Andresen Lars, Nielsen Jens, Christensen Jan Pravsgaard, Skov Søren
Abstract excerpt
Vesicular stomatitis virus (VSV) has recently gained attention for its oncolytic ability in cancer treatment. Initially, we hypothesized that VSV infection could increase immune recognition of cancer cells through induction of the immune stimulatory NKG2D-ligands. Here we show that VSV infection leads to a robust induction of MICA mRNA expression, however the subsequent surface expression is potently hindered....
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