Article

CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma

2023-06-09

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Allogeneic bone marrow transplant (alloBMT) is curative for hematologic malignancies through the graft-versus-tumor (GVT) effect but has been ineffective for solid tumors like osteosarcoma (OS). OS expresses CD155 which interacts strongly with inhibitory receptors TIGIT and CD96 but also binds to activating receptor DNAM-1 on natural killer (NK) cells. CD155 has never been t...

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Literature Corpus work: 4bdaafce-b9df-5131-9448-e6691fa501d3
DOI: 10.1101/2023.06.07.544144

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