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Oncolytic virus treatment differentially affects the CD56 <sup>dim</sup> and CD56 <sup>bright</sup> NK cell subsets <i>in vivo</i> and regulates a spectrum of human NK cell activity

2020-12-16

Abstract excerpt

Natural killer (NK) cells protect against intracellular infection and cancer. These properties are exploited in oncolytic virus (OV) therapy, where anti-viral responses enhance anti-tumour immunity. We have analysed the mechanism by which reovirus, an oncolytic dsRNA virus, modulates human NK cell activity. Reovirus activates NK cells in a type I interferon (IFN-I) dependent manner, resulting in STAT1 and STAT4 si...

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Literature Corpus work
95181b03-2433-56a0-a5ea-b181cdd20350
DOI
10.1101/2020.12.16.423062
Open publication

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Oncolytic virus treatment differentially affects the CD56 <sup>dim</sup> and CD56 <sup>bright</sup> NK cell subsets <i>in vivo</i> and regulates a spectrum of human NK cell activityDOI 10.1101/2020.12.16.423062
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