Article
Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.
Human gene therapy - 1 Oct 2012
Sutlu Tolga, Nyström Sanna, Gilljam Mari, Stellan Birgitta, Applequist Steven E, Alici Evren
Abstract excerpt
Adoptive immunotherapy with genetically modified natural killer (NK) cells is a promising approach for cancer treatment. Yet, optimization of highly efficient and clinically applicable gene transfer protocols for NK cells still presents a challenge. In this study, we aimed at identifying conditions under which optimum lentiviral gene transfer to NK cells can be achieved. Our results demonstrate that stimulation...
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