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Article

α1F64 Residue at GABA(A) receptor binding site is involved in gating by influencing the receptor flipping transitions.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Feb 2014

Szczot Marcin, Kisiel Magdalena, Czyzewska Marta M, Mozrzymas Jerzy W

Abstract excerpt

GABA receptors (GABAARs) mediate inhibition in the adult brain. These channels are heteropentamers and their ligand binding sites are localized at the β+ / α- interfaces. As expected, mutations of binding-site residues affect binding kinetics but accumulating evidence indicates that gating is also altered, although the underlying mechanisms are unclear. We investigated the impact of the hydrophobic box residue...

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Identifiers

PMID: 24573278
DOI: 10.1523/JNEUROSCI.2533-13.2014
PMCID: PMC6795308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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