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Article

A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics.

Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008

Venkatachalan Srinivasan P, Czajkowski Cynthia

Abstract excerpt

Chemical signaling in the brain involves rapid opening and closing of ligand gated ion channels (LGICs). LGICs are allosteric membrane proteins that transition between multiple conformational states (closed, open, and desensitized) in response to ligand binding. While structural models of cys-loop LGICs have been recently developed, our understanding of the protein movements underlying these conformational...

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Identifiers

PMID: 18757734
DOI: 10.1073/pnas.0801854105
PMCID: PMC2533236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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