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Article

The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.

The Journal of physiology - 15 Aug 2006

Keramidas Angelo, Kash Thomas L, Harrison Neil L

Abstract excerpt

The binding of the neurotransmitter GABA induces conformational changes in the GABAA receptor (GABAAR), leading to the opening of a gate that controls ion permeation through an integral transmembrane pore. A number of structural elements within each subunit, located near the membrane interface, are believed to undergo relative movements during this activation process. In this study, we explored the functional...

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Identifiers

PMID: 16763005
DOI: 10.1113/jphysiol.2005.102756
PMCID: PMC1819431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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