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Article

Prognostic Value of Germline DNA Repair Gene Mutations in De Novo Metastatic and Castration-Sensitive Prostate Cancer.

The oncologist - 1 Jul 2020

Wei Yu, Wu Junlong, Gu Weijie, Wang Jun, Lin Guowen, Qin Xiaojian, Dai Bo, Gan Hualei, Ye Dingwei, Zhu Yao

Abstract excerpt

BACKGROUND: Germline DNA damage repair gene mutations (gDDRm) have been found in approximately 12% of patients with metastatic prostate cancer (mPCa). Previous studies of the clinical impact of gDDRm have mainly been in the setting of metastatic castration-resistant prostate cancer (mCRPC). This study aimed to determine the prognostic value of gDDRm in de novo metastatic and castration-sensitive prostate cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32190957
DOI: 10.1634/theoncologist.2019-0495
PMCID: PMC7356812

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