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Highly Efficient Site-Specific Mutagenesis in Malaria Mosquitoes Using CRISPR

12 Dec 2017

Abstract excerpt

Abstract Anopheles mosquitoes transmit at least 200 million annual malaria infections worldwide. Despite considerable genomic resources, mechanistic understanding of biological processes in Anopheles has been hampered by a lack of tools for reverse genetics. Here, we report successful application of the CRISPR/Cas9 system for highly efficient, site-specific mutagenesis in the diverse malaria vectors Anopheles...

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PMID: 29233915
DOI: 10.1534/g3.117.1134

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