Article

Genome-engineering with CRISPR-Cas9 in the mosquito <i>Aedes aegypti</i>

2014-12-27

Abstract excerpt

The mosquito Aedes aegypti is a potent vector of the Chikungunya, yellow fever, and Dengue viruses, which result in hundreds of millions of infections and over 50,000 human deaths per year. Loss-of-function mutagenesis in Ae. aegypti has been established with TALENs, ZFNs, and homing endonucleases, which require the engineering of DNA-binding protein domains to generate target specificity for a particular stretc...

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Literature Corpus work: e2dbea2a-369e-59b2-b1c7-7d5e0b8b46d7
DOI: 10.1101/013276

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