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Article

P38 mitogen-activated protein kinase promotes dedifferentiation of primary articular chondrocytes in monolayer culture.

Journal of cellular and molecular medicine - 1 Apr 2013

Rosenzweig Derek H, Ou Sing J, Quinn Thomas M

Abstract excerpt

Articular cartilage is an avascular tissue with poor regenerative capacity following injury, a contributing factor to joint degenerative disease. Cell-based therapies for cartilage tissue regeneration have rapidly advanced; however, expansion of autologous chondrocytes in vitro using standard methods causes 'dedifferentiation' into fibroblastic cells. Mitogen-activated protein kinase (MAPK) signalling is crucial...

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Identifiers

PMID: 23480786
DOI: 10.1111/jcmm.12034
PMCID: PMC3822651

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