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Article

The modulation of the oxidative stress response in chondrocytes by Wip1 and its effect on senescence and dedifferentiation during in vitro expansion.

Biomaterials - 1 Mar 2013

Cha Byung-Hyun, Lee Ji-Seon, Kim Sung Won, Cha Hyuk-Jin, Lee Soo-Hong

Abstract excerpt

Obtaining a sufficient number of cells ex vivo for tissue regeneration, which are appropriate for cartilage repair, requires improved techniques for the continuous expansion of chondrocytes in a manner that does not change their innate characteristics. Rapid senescence or dedifferentiation during in vitro expansion results in loss of chondrocyte phenotype and the formation of fibrous cartilage replacement tissue,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23306038
DOI: 10.1016/j.biomaterials.2012.12.009

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