Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of periostin function impairs ligament fibroblast activity and facilitates ROS ‐mediated cellular senescence

20 Aug 2024

Abstract excerpt

Abstract Anterior cruciate ligament (ACL) injuries pose a significant challenge due to their limited healing potential, often resulting in premature arthritis. The factors and mechanisms contributing to this inadequate healing process remain elusive. During the acute phase of injury, ACL tissues express elevated periostin levels that decline over time. The functional significance of periostin in ligament biology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Knee injuries and reconstruction techniques
Share to Tendon Structure and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39162681
DOI: 10.1096/fj.202302615rr

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of periostin function impairs ligament fibroblast activity and facilitates ROS ‐mediated cellular senescencePMID 39162681Read ↗

Cellular Senescence Impairs Tendon Extracellular Matrix Remodeling in Response to Mechanical UnloadingSemantic proximity Read ↗

Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implicationsSemantic proximity Read ↗

Uncovering the cellular and molecular changes in tendon stem/progenitor cells attributed to tendon aging and degenerationSemantic proximity Read ↗

Pro-fibrotic phenotype of human skin fibroblasts induced by periostin via modulating TGF-β signalingSemantic proximity Read ↗

Periostin differentially induces proliferation, contraction and apoptosis of primary Dupuytren's disease and adjacent palmar fascia cellsSemantic proximity Read ↗

RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossificationSemantic proximity Read ↗

The combination of mitogenic stimulation and cell cycle arrest induces senescence in equine and human cartilage explantsSemantic proximity Read ↗

AMP-activated protein kinase (AMPK) is essential for tendon homeostasis and prevents premature senescence and ectopic calcificationSemantic proximity Read ↗

Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescenceSemantic proximity Read ↗

Deletion of p21 expression accelerates cartilage tissue repair via chondrocyte proliferation.Semantic proximity Read ↗

Changes in Transcriptome-Wide Gene Expression of Anterior Cruciate Ligament Tears Based on Time From InjurySemantic proximity Read ↗

Compliant substrates mitigate the senescence associated phenotype of stress induced mesenchymal stromal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.