Article
Evaluating the Role of Genetic Variants on first-line antiepileptic drug response in North India: Significance of SCN1A and GABRA1 Gene Variants in Phenytoin Monotherapy and its Serum Drug Levels.
CNS neuroscience & therapeutics - 1 Sept 2016
Baghel Ruchi, Grover Sandeep, Kaur Harpreet, Jajodia Ajay, Rawat Chitra, Srivastava Ankit, Kushwaha Suman, Agarwal Rachna, Sharma Sangeeta, Kukreti Ritushree
Abstract excerpt
AIM: The present study aimed to evaluate association of genetic variants on drug response and therapy optimization parameters in patients treated with first-line antiepileptic drugs (AEDs). Genetic variants from ion channels, their functionally related genes, and synaptic vesicle cycle (SVC) genes with a potential role in epilepsy pathophysiology were thus prioritized. METHODS: A total of 12 genes from ion...
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